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" 'Where is the missing heritability?' is a question asked frequently in genetic research. The difficulty seems to come down to the common disease/common variant hypothesis not holding up." » Read more
Design and Analysis of GWAS using CNVs

Archived Webcasts

SNP and Variation Suite 7 overview

Introduction to SNP & Variation Suite 7

Dr. Christophe Lambert and John Nord of Golden Helix introduce the new features and capabilities released in SNP & Variation Suite v7.

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Genotype Calling and Imputation with BEAGLE and BEAGLECALL

Genotype Calling and Imputation with BEAGLE and BEAGLECALL

August 24, 2010
In this webcast, Dr. Lambert discusses the tools BEAGLECALL (to re-call genotypes) and BEAGLE (for imputation) including their advantages, limitations, when to utilize each, and comparisons to other methods.

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Introducing SVS 7.3

Introducing SVS 7.3

July 28, 2010
The third installment of SVS 7 extends our dedication to a rich, multi-dimensional analytic approach to genetic research, empowering more people than ever to uncover the genetic cause of disease, drug response, and other conditions.

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Quality Assurance and Data Prep for SNP and CNV Studies

Achieving Genome-Wide Success Part III: Quality Assurance and Data Prep for SNP and CNV Studies

December 9, 2009
The following recording is from the Golden Helix ancillary event hosted in conjunction with the 2009 American Society of Human Genetics annual meeting. Dr. Lambert examines best practices, pitfalls, and analytic methods learned from over 30 genome-wide SNP, CNV, and eQTL association studies.

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Overcoming data quality and copy number detection in GWAS

ASHG 2009 Ancillary Event: Achieving Genome-Wide Success from SNPs to CNVs to eQTL

October 22, 2009
The following recording is from the Golden Helix ancillary event hosted in conjunction with the 2009 American Society of Human Genetics annual meeting. Dr. Lambert examines best practices, pitfalls, and analytic methods learned from over 30 genome-wide SNP, CNV, and eQTL association studies.

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Overcoming data quality and copy number detection in GWAS

Achieving Genome-Wide Success Part II: Study Design in SNP and CNV Studies

October 7, 2009
Part 2 of the Achieving Genome-Wide Success, Dr. Christophe Lambert examines the effects of poor study design in genetic association studies. Strategies and techniques for good study design will also be discussed.

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Overcoming data quality and copy number detection in GWAS

IGES 2009: Overcoming Data Quality and Copy Number Detection Issues in Genome-Wide CNV Association Studies

October 19, 2009
The following is a recording of Dr. Christophe Lambert's invited talk at the International Genetic Epidemiology Society 2009 Annual Meeting.

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Overcoming data quality and copy number detection in GWAS

Joint Statistical Meeting 2009 Talk

August 5, 2009
Overcoming data quality and copy number detection issues in genome-wide CNV association studies,

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Achieving Genome-Wide Success in SNP and CNV Studies

Achieving Genome-Wide Success Part I

February 18, 2009
Dr. Christophe Lambert examines some of the more persistent challenges he's experienced in SNP and CNV genome-wide association studies, and the novel methods used to overcome them.

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GWAS on Alzheimers

Genome-Wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

December 2, 2008
Dr. Christoph Lange presents an overview of his most recent research on Alzheimer's Disease with PBAT.

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Genome Wide SNP and CNV Association Studies Identify Genetic Factors for Lung Cancer

October 28, 2008
Dr. Amos describes the approaches he and his team at The University of Texas have taken in identifying genetic factors influencing the risk for lung cancer development.

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IGES 2008 Talk: Methods and Discoveries Drawn from 20 Whole Genome Copy Number Variation Studies

September 16, 2008
Includes discussion of Wellcome Trust copy number variation association results.

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Emerging Methods in Whole Genome CNV Association

July 23, 2008
Discussion of key strategies, methods and workflows used on over twenty whole genome copy number variation (CNV) association studies.

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On the Analysis of Copy-Number Variations in Genome-Wide Association Studies: A Translation of the Family-Based Association Test

March 18, 2008
Dr. Christoph Lange presents an overview of his recent work with Dr. Juliana Ionita-Laza on analyzing copy number variations in family-based association studies using PBAT.

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On the Replication of Genetic Associations: Timing Can Be Everything

April 15, 2008
Dr. Jessica Lasky Su presents discusses her research and the PBAT methods used to find a whole genome age-dependent association that was replicated in five of eight studies.

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SNP, ROH and CNV Association Analysis Overview with Affymetrix SNP Arrays 5.0 and 6.0

February 7, 2008
An overview of various whole genome methods and workflows for analyzing Affymetrix SNP and copy number data with the SNP & Variation Suite.

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Whole Genome Copy Number Association Analysis with Golden Helix

November 14, 2007
A first look at the CNV segmentation and association methods implemented in the Copy Number Analysis Module (CNAM).

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Using Runs of Homozygosity to Identify Recessive Loci

January 24, 2008
Dr. Todd Lencz address the theoretical and statistical underpinnings of whole genome homozygosity association (WGHA) and its potential utility in studies of complex disease.

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Whole Genome Association Study of Schizophrenia

May 9, 2007
Dr. Todd Lencz presents the analysis and results of his whole genome association study of Schizophrenia.

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